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Spirit Damage is a form of damage dealt by most abilities and some items. It is modifiable by obtaining 
Spirit Power, and scales with the respective ability or item’s Spirit 
Scaling. Certain items deals additional Spirit Damage if a condition is met.
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Video explaining Spirit Damage
Target Modifiers
Spirit Resistance
: Main article: 
Damage Resistance
Incoming damage is reduced by the target’s Spirit Resist and increased by the attacker’s Spirit Resist Reduction. These stats 
stack multiplicatively. For a detailed breakdown on how multiple items stack, see the main page.
NPCs
Attacks from Walkers, Shrines and Patrons deal Spirit Damage.
Sources
There are several items that deal Spirit Damage, but called in a different name or applied in a specific manner. (Not a comprehensive list)
Alchemical Fire deals increasing Spirit Damage per second in an area.
Mystic Shot makes the player’s bullet deal 40 
x1.2 Spirit Damage every 9 seconds.
Tesla Bullets deals 33 x0.19 Shock Damage on hit and on jump.
Torment Pulse deals 25 x0.23 Pulse Damage every 1.4s (scaling with Spirit Power).
Toxic Bullets deals 1.9% x0.005 Bleed Damage based on current 
health per second.
See also Spirit Power for a list of items that grant Spirit Power.